Press Release

$1.67M NIH Grant Brings Scene Health’s Medication Support to Florida Pediatric Heart Transplant Centers

April 6, 2023
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The Guide to Managing Medication Adherence to Improve Outcomes and Quality Metrics

BALTIMORE--Children who need life-changing heart transplants in Florida will be able to receive free support to help improve medication adherence, which can potentially reduce the frequency of organ rejection over the next two years, thanks to a National Institutes of Health (NIH)/National Heart Lung and Blood Institute (NHLBI) Small Business Innovation Research (SBIR) award for $1.67M to Scene Health (formerly emocha Health), a leading video medication adherence platform.

Principal investigators Dr. Dipankar Gupta, M.D., pediatric transplant physician at the University of Florida’s Congenital Heart Center, and Dr. Michael Killian, Ph.D., MSW, a College of Social Work faculty member at Florida State University, will lead the joint project enabling pediatric transplant physicians in Florida to deploy Scene’s platform to provide personalized interventions to improve overall medication adherence to immunosuppressive therapy, prevent related hospitalizations, and reduce the potential of rejection among adolescent heart transplant patients.

Medicines that modulate the transplant patients’ immune systems can help the body fend off organ rejection, which is a key risk. Teens, in particular, have difficulty adhering to the regimen. The grant will build on the published findings of a 12-week pilot study to assess the feasibility, acceptability and efficacy of using video DOT (Directly Observed Therapy) to help adolescent heart transplant patients track and improve adherence. The pilot study found that those who completed the program had a 90.1% adherence rate. For comparison, five of the six patients who did not begin video DOT or dropped out of the study were hospitalized or experienced episodes of acute organ rejection. This grant will allow the investigators to perform a randomized control trial to assess the impact of video DOT on a larger scale and across multiple pediatric heart transplant centers.

The pilot study, led by Drs. Killian and Gupta, utilized the collective strengths of an interdisciplinary research team including Dr. Mia Lustria, Ph.D., a professor at Florida State’s School of Information, to tackle this difficult problem.

Drs. Killian and Gupta have continued to lean into the interdisciplinary nature of research in pediatric transplant health, launching the Initiative for the Advancement of Pediatric Transplant Health Research. The initiative taps into a statewide network of health researchers, clinicians and pediatric heart transplant centers.

“This grant represents an important integrative and holistic approach to improving the lives of vulnerable populations, including pediatric organ recipients and their families, through science and research,” Killian said.

Medication adherence is critical for pediatric heart transplant patients, especially adolescent patients who struggle to take their medications consistently, often due to social factors. Failure to adhere to the medication regimen can result in the rejection of the transplanted heart, leading to hospitalization or even death. Despite potential catastrophic consequences, nonadherence rates are as high as 60% in teenage patients.

"This NIH grant will allow Scene Health to expand our efforts to support medication adherence in one of the highest-risk patient populations,” notes Sebastian Seiguer, co-founder and CEO of Scene Health. “Our video medication adherence platform uses a format young people are accustomed to — video engagement — to empower them to take control of their health, and our clinical pilot study showed it makes a real difference in their outcomes.”

Scene’s mobile app allows patients to connect with a care team of pharmacists, nurses, and health coaches through asynchronous daily video check-ins anytime and anywhere. Scene makes it fun for patients to stay on top of their medications, helps them address any medication challenges, and empowers them to improve their health by identifying and addressing barriers to adherence related to social determinants of health.

Co-Principal Investigator of the new project, Dr. Gupta, added: "Use of video medication adherence platforms has the potential to ultimately improve outcomes for pediatric heart transplant patients, particularly for adolescent patients who often struggle to stick to medication regimens. We are excited to see this technology supported and expanded throughout Florida.”

The grant announcement comes on the heels of the CDC endorsement of video Directly Observed Therapy (video DOT) as equivalent to in-person DOT for tuberculosis treatment. With roots in ​​using video DOT to secure adherence for tuberculosis and hepatitis C patients, Scene has now expanded to support patients across multiple chronic and infectious conditions, including diabetes, asthma, cholesterol, opioid use disorder, hepatitis C, tuberculosis, hypertension, solid organ transplants, and sickle cell disease. Scene’s approach has been validated in over 12 clinical research studies across 19 peer-reviewed publications. At least 25 independent research studies and trials are completed, underway, or planned using Scene’s platform to secure adherence.

This press release includes information about a study to be supported by the National Heart, Lung, And Blood Institute of the National Institutes of Health under Award Number R44HL167591. Research content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.

About Scene

Scene’s 360° model of care scales and enhances the gold standard of medication adherence, Directly Observed Therapy. Combining personalized video coaching, education, and motivational content, Scene brings healthcare professionals, patients, and their families together to solve the $500B medication nonadherence problem. Hundreds of customers across the healthcare landscape use Scene’s medication engagement program to improve medication adherence for patients with chronic and infectious diseases. Learn more at www.scene.health


Contact: Liz DeForest
Email: scene@theblissgrp.com

Guide
The Guide to Managing Medication Adherence to Improve Outcomes and Quality Metrics
Guide
Download  the Guide to Managing Medication Adherence to Improve Outcomes and Quality Metrics
The Guide to Managing Medication Adherence to Improve Outcomes and Quality Metrics

Download this Guide to Managing Medication Adherence to learn about the medication adherence problem, its many and varied causes, the available tools, and the comprehensive solution.

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